LFA-3, CD44, AND CD45: Physiologic triggers of human monocyte TNF and IL-1 release

Deborah S.A. Webb, Yoji Shimizu, Gijs A. Van Seventer, Stephen Shaw, Theresa L. Gerrard

Research output: Contribution to journalArticlepeer-review

268 Scopus citations

Abstract

The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators ofthe immune response, but the physiologic stimuli for their release remain lagely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalScience
Volume249
Issue number4974
DOIs
StatePublished - Jan 1 1990

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