Levodopa-induced dyskinesias in Parkinson’s disease

Stephanie L. Alberico, Nandakumar S. Narayanan

Research output: Chapter in Book/Report/Conference proceedingChapter


A major problem in treating Parkinson’s disease is that up to 80% of patients will develop levodopa-induced dyskinesias (LIDs). These abnormal involuntary movements result in difficulty in controlling movements and contribute to further disability in Parkinson’s disease. Despite the long history of levodopa as the leading therapy, it remains unknown how these abnormal movements develop. In this chapter, we review the pathophysiology of LIDs including recent work implicating different neuronal populations in the striatum.

Original languageEnglish (US)
Title of host publicationDiagnosis and Management in Parkinson’s Disease
Subtitle of host publicationThe Neuroscience of Parkinson’s Disease, Volume 1
Number of pages13
ISBN (Electronic)9780128159460
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.


  • Abnormal involuntary movements
  • Cholinergic interneurons
  • Fast spiking interneurons
  • Levodopa-induced dyskinesia
  • Medium spiny neurons
  • Striatum


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