Keyphrases
Pharmacokinetics
100%
Levetiracetam
100%
Rat Model
100%
Brain Uptake
100%
Lateral Fluid Percussion
100%
Nave
28%
Bolus Injection
28%
Moderate to Severe Traumatic Brain Injury
28%
Subcutaneous Infusion
28%
Epilepsy
14%
Dose Selection
14%
Traumatic Brain Injury
14%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
14%
Treatment Protocol
14%
Safety Profile
14%
Modeling Approach
14%
Targeted Drugs
14%
Antiepileptogenic
14%
Bioinformatics Study
14%
Optimal Treatment
14%
Drug Exposure
14%
Post-traumatic Epilepsy
14%
First-order
14%
Sprague-Dawley Rats
14%
Epileptogenesis
14%
Volume of Distribution
14%
Pharmacokinetic Model
14%
Injury Model
14%
Brain-to-plasma Ratio
14%
Pharmacokinetic Modeling
14%
One-compartment
14%
High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS)
14%
Pharmacokinetic Data
14%
Loading Dose
14%
Good Safety
14%
Non-compartmental Analysis
14%
Parameter Optimizing
14%
High Performance Liquid
14%
Screening Phase
14%
Seizure Prophylaxis
14%
Parietal Area
14%
MS Method
14%
Specified Time
14%
Injury Parameters
14%
Pharmacology, Toxicology and Pharmaceutical Science
Rat Model
100%
Levetiracetam
100%
Pharmacokinetics
100%
Traumatic Brain Injury
42%
Subcutaneous Injection
28%
High Performance Liquid Chromatography
14%
Pharmacokinetic Modeling
14%
Sprague Dawley Rat
14%
Traumatic Epilepsy
14%
Epileptogenesis
14%
Intraperitoneal Injection
14%
Absorption (Pharmacokinetics)
14%
Volume of Distribution
14%