Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.
Bibliographical noteFunding Information:
This work was supportedby NIDA GrantsD A02717a nd DA03999 and the Departmenot f VeteransA ffairs. D.C.J. was supported under NIDA TrainingG rantD A07097.T he authorsw ish to thank Martha Grace for her expert technicaal ssistancteh roughoutth e project.
- Discriminative stimulus
- Drug discrimination
- Food intake
- NPY 20-36
- NPY receptor
- Neuropeptide Y (NPY)