Leukodystrophy: Basic and clinical

Gerald V. Raymond

doi:10.1007/978-3-319-57193-5_14

Leukodystrophy: Basic and clinical

Gerald V. Raymond

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

Leukodystrophies are serious, progressive, genetic disorders of CNS myelin. They may result from abnormalities of the oligodendrocyte or any of the other of myriad of supporting cells or tissues. With recent developments in neuroimaging, their presence is becoming increasingly noted even in situations where they were not suspected. More importantly, new genetic tools have improved our ability to diagnose. An understanding of pathogenesis is still evolving, but it is expected that this will assist in developing targeted therapies for these devastating disorders.

Original language	English (US)
Title of host publication	Advances in Neurobiology
Publisher	Springer New York LLC
Pages	365-382
Number of pages	18
DOIs	https://doi.org/10.1007/978-3-319-57193-5_14
State	Published - Jan 1 2017

Publication series

Name	Advances in Neurobiology
Volume	15
ISSN (Print)	2190-5215

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adrenoleukodystrophy
Alexander disease
Globoid cell leukodystrophy
Leukodystrophy
Myelin

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10.1007/978-3-319-57193-5_14

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AB - Leukodystrophies are serious, progressive, genetic disorders of CNS myelin. They may result from abnormalities of the oligodendrocyte or any of the other of myriad of supporting cells or tissues. With recent developments in neuroimaging, their presence is becoming increasingly noted even in situations where they were not suspected. More importantly, new genetic tools have improved our ability to diagnose. An understanding of pathogenesis is still evolving, but it is expected that this will assist in developing targeted therapies for these devastating disorders.

KW - Adrenoleukodystrophy

KW - Alexander disease

KW - Globoid cell leukodystrophy

KW - Leukodystrophy

KW - Myelin

UR - https://www.scopus.com/pages/publications/85021738802

UR - https://www.scopus.com/pages/publications/85021738802#tab=citedBy

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M3 - Chapter

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T3 - Advances in Neurobiology

SP - 365

EP - 382

BT - Advances in Neurobiology

PB - Springer New York LLC

ER -

Leukodystrophy: Basic and clinical

Abstract

Publication series

UN SDGs

Keywords

Publisher link

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