Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein; B. A. Hirsch; D. Hammerschmidt; R. C. McGlennen; P. L. Nguyen; C. M. Verfaillie

doi:10.1038/sj.bmt.1703577

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein
, B. A. Hirsch
, D. Hammerschmidt
, R. C. McGlennen
, P. L. Nguyen
, C. M. Verfaillie

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34⁺ cells.

Original language	English (US)
Pages (from-to)	999-1003
Number of pages	5
Journal	Bone marrow transplantation
Volume	29
Issue number	12
DOIs	https://doi.org/10.1038/sj.bmt.1703577
State	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myeloid luekemia
Allogeneic hematopoietic stem cell transplant
Myelodysplastic syndrome

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10.1038/sj.bmt.1703577

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title = "Leukemia in donor cells after allogeneic hematopoietic stem cell transplant",

abstract = "The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.",

keywords = "Acute myeloid luekemia, Allogeneic hematopoietic stem cell transplant, Myelodysplastic syndrome",

author = "Brunstein, \{C. G.\} and Hirsch, \{B. A.\} and D. Hammerschmidt and McGlennen, \{R. C.\} and Nguyen, \{P. L.\} and Verfaillie, \{C. M.\}",

year = "2002",

doi = "10.1038/sj.bmt.1703577",

language = "English (US)",

volume = "29",

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TY - JOUR

T1 - Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

AU - Brunstein, C. G.

AU - Hirsch, B. A.

AU - Hammerschmidt, D.

AU - McGlennen, R. C.

AU - Nguyen, P. L.

AU - Verfaillie, C. M.

PY - 2002

Y1 - 2002

N2 - The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

AB - The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

KW - Acute myeloid luekemia

KW - Allogeneic hematopoietic stem cell transplant

KW - Myelodysplastic syndrome

UR - https://www.scopus.com/pages/publications/0036321705

UR - https://www.scopus.com/pages/publications/0036321705#tab=citedBy

U2 - 10.1038/sj.bmt.1703577

DO - 10.1038/sj.bmt.1703577

M3 - Article

C2 - 12098070

AN - SCOPUS:0036321705

SN - 0268-3369

VL - 29

SP - 999

EP - 1003

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 12

ER -

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

Abstract

UN SDGs

Keywords

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