Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein; B. A. Hirsch; D. Hammerschmidt; R. C. McGlennen; P. L. Nguyen; C. M. Verfaillie

doi:10.1038/sj.bmt.1703577

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein, B. A. Hirsch, D. Hammerschmidt, R. C. McGlennen, P. L. Nguyen, C. M. Verfaillie

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34⁺ cells.

Original language	English (US)
Pages (from-to)	999-1003
Number of pages	5
Journal	Bone marrow transplantation
Volume	29
Issue number	12
DOIs	https://doi.org/10.1038/sj.bmt.1703577
State	Published - 2002

Keywords

Acute myeloid luekemia
Allogeneic hematopoietic stem cell transplant
Myelodysplastic syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1038/sj.bmt.1703577

Find It

Find It at U of M Libraries

Cite this

@article{21ca81a4bbbb4f51a0f38596dbecf7bb,

title = "Leukemia in donor cells after allogeneic hematopoietic stem cell transplant",

abstract = "The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.",

keywords = "Acute myeloid luekemia, Allogeneic hematopoietic stem cell transplant, Myelodysplastic syndrome",

author = "Brunstein, {C. G.} and Hirsch, {B. A.} and D. Hammerschmidt and McGlennen, {R. C.} and Nguyen, {P. L.} and Verfaillie, {C. M.}",

year = "2002",

doi = "10.1038/sj.bmt.1703577",

language = "English (US)",

volume = "29",

pages = "999--1003",

journal = "Bone marrow transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

AU - Brunstein, C. G.

AU - Hirsch, B. A.

AU - Hammerschmidt, D.

AU - McGlennen, R. C.

AU - Nguyen, P. L.

AU - Verfaillie, C. M.

PY - 2002

Y1 - 2002

N2 - The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

AB - The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

KW - Acute myeloid luekemia

KW - Allogeneic hematopoietic stem cell transplant

KW - Myelodysplastic syndrome

UR - http://www.scopus.com/inward/record.url?scp=0036321705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036321705&partnerID=8YFLogxK

U2 - 10.1038/sj.bmt.1703577

DO - 10.1038/sj.bmt.1703577

M3 - Article

C2 - 12098070

AN - SCOPUS:0036321705

SN - 0268-3369

VL - 29

SP - 999

EP - 1003

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 12

ER -

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

Abstract

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this