Lethality of pentazocine and tripelennamine combinations in mice housed individually and in groups

Alan Poling, John Kesselring, Robert G. Sewell, James Cleary

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Lethality of 80 mg/kg pentazocine alone; 40 mg/kg tripelennamine 20 mg/kg tripelennamine in combination with 40, 60, and 80 mg/kg pentazocine; and 40 mg/kg tripelennamine in combination with 10, 20, and 40 mg/kg pentazocine was determined in mice housed individually and in groups. Results indicate that the lethality of pentazocine and tripelennamine combinations in mice is (1) dose-dependent, (2) potentiated relative to either drug alone, and (3) greater in group-housed than in individually-housed animals.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume18
Issue number1
DOIs
StatePublished - Jan 1983

Keywords

  • Aggregate toxicity
  • Drug interaction
  • Lethality
  • Mice
  • Pentazocine
  • Tripelennamine

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