Lessons learned from gene transfer approaches

C. H. Evans, S. C. Ghivizzani, E. R. Lechman, Z. Mi, D. Jaffurs, P. D. Robbins

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools for the study of synovitis and other aspects of the biology of joints in health and disease. This article reviews briefly the results of experiments in which selected genes have been transferred to the knee joints of healthy rabbits and rabbits with antigen-induced arthritis.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalArthritis Research
Volume1
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Animal model
  • Cartilage
  • Cytokine
  • Gene therapy
  • Growth factor
  • Rheumatoid arthritis
  • Synovium

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