Abstract
To further define the role of the external segment of the globus pallidus (GPe) in the development of parkinsonian motor signs, two rhesus monkeys were made parkinsonian with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behavioral assessments of bradykinesia and akinesia as well as single neuron recordings in the internal segment of the globus pallidus (GPi) were performed in both monkeys before and after ablating the sensorimotor portion of GPe. The effects of apomorphine on behavior and neuronal activity were also assessed in the parkinsonian monkeys before and after GPe ablation. We found that lesions in GPe exacerbated parkinsonian symptoms, altered neuronal activity in GPi, and reduced the therapeutic effects of apomorphine. These results support the hypothesis that GPe can influence GPi neuronal activity and is directly involved in parkinsonism. In addition, these data suggest that the inclusion of GPe in pallidotomy lesions for the treatment of Parkinson's disease can block the beneficial effects of antiparkinsonian medications and should be avoided.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 446-453 |
| Number of pages | 8 |
| Journal | Experimental Neurology |
| Volume | 199 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2006 |
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Keywords
- Globus pallidus
- MPTP
- Monkey
- Pallidotomy
- Parkinson's disease
- Radio frequency ablation
Cite this
Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms. / Zhang, Jianyu; Russo, Gary S.; Mewes, Klaus; Rye, David B.; Vitek, Jerrold L.
In: Experimental Neurology, Vol. 199, No. 2, 01.06.2006, p. 446-453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms
AU - Zhang, Jianyu
AU - Russo, Gary S.
AU - Mewes, Klaus
AU - Rye, David B.
AU - Vitek, Jerrold L.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - To further define the role of the external segment of the globus pallidus (GPe) in the development of parkinsonian motor signs, two rhesus monkeys were made parkinsonian with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behavioral assessments of bradykinesia and akinesia as well as single neuron recordings in the internal segment of the globus pallidus (GPi) were performed in both monkeys before and after ablating the sensorimotor portion of GPe. The effects of apomorphine on behavior and neuronal activity were also assessed in the parkinsonian monkeys before and after GPe ablation. We found that lesions in GPe exacerbated parkinsonian symptoms, altered neuronal activity in GPi, and reduced the therapeutic effects of apomorphine. These results support the hypothesis that GPe can influence GPi neuronal activity and is directly involved in parkinsonism. In addition, these data suggest that the inclusion of GPe in pallidotomy lesions for the treatment of Parkinson's disease can block the beneficial effects of antiparkinsonian medications and should be avoided.
AB - To further define the role of the external segment of the globus pallidus (GPe) in the development of parkinsonian motor signs, two rhesus monkeys were made parkinsonian with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behavioral assessments of bradykinesia and akinesia as well as single neuron recordings in the internal segment of the globus pallidus (GPi) were performed in both monkeys before and after ablating the sensorimotor portion of GPe. The effects of apomorphine on behavior and neuronal activity were also assessed in the parkinsonian monkeys before and after GPe ablation. We found that lesions in GPe exacerbated parkinsonian symptoms, altered neuronal activity in GPi, and reduced the therapeutic effects of apomorphine. These results support the hypothesis that GPe can influence GPi neuronal activity and is directly involved in parkinsonism. In addition, these data suggest that the inclusion of GPe in pallidotomy lesions for the treatment of Parkinson's disease can block the beneficial effects of antiparkinsonian medications and should be avoided.
KW - Globus pallidus
KW - MPTP
KW - Monkey
KW - Pallidotomy
KW - Parkinson's disease
KW - Radio frequency ablation
UR - http://www.scopus.com/inward/record.url?scp=33745248385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745248385&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2006.01.006
DO - 10.1016/j.expneurol.2006.01.006
M3 - Article
C2 - 16487515
AN - SCOPUS:33745248385
VL - 199
SP - 446
EP - 453
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -