Leptin inhibition of insulin secretion from isolated human islets

H. C. Fehmann; P. Berghöfer; D. Brandhorst; H. Brandhorst; B. Hering; R. G. Bretzel; B. Göke

doi:10.1007/s005920050083

Leptin inhibition of insulin secretion from isolated human islets

H. C. Fehmann, P. Berghöfer, D. Brandhorst, H. Brandhorst, B. Hering, R. G. Bretzel, B. Göke

Surgery

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Abstract

Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic β-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an 'adipo-insular axis' in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.

Original language	English (US)
Pages (from-to)	249-252
Number of pages	4
Journal	Acta Diabetologica
Volume	34
Issue number	4
DOIs	https://doi.org/10.1007/s005920050083
State	Published - Dec 1997

Keywords

Endocrine pancreas
Insulin secretion
Leptin
β-cells

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s005920050083

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AU - Fehmann, H. C.

AU - Berghöfer, P.

AU - Brandhorst, D.

AU - Brandhorst, H.

AU - Hering, B.

AU - Bretzel, R. G.

AU - Göke, B.

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N2 - Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic β-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an 'adipo-insular axis' in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.

AB - Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic β-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an 'adipo-insular axis' in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.

KW - Endocrine pancreas

KW - Insulin secretion

KW - Leptin

KW - β-cells

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Leptin inhibition of insulin secretion from isolated human islets

Abstract

Keywords

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