Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates

Yari Cabezas, Laurent Legentil, Florence Robert-Gangneux, Franck Daligault, Sorya Belaz, Caroline Nugier-Chauvin, Sylvain Tranchimand, Charles Tellier, Jean Pierre Gangneux, Vincent Ferrières

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents.

Original languageEnglish (US)
Pages (from-to)8393-8404
Number of pages12
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number31
DOIs
StatePublished - Aug 21 2015

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