TY - JOUR
T1 - Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates
AU - Cabezas, Yari
AU - Legentil, Laurent
AU - Robert-Gangneux, Florence
AU - Daligault, Franck
AU - Belaz, Sorya
AU - Nugier-Chauvin, Caroline
AU - Tranchimand, Sylvain
AU - Tellier, Charles
AU - Gangneux, Jean Pierre
AU - Ferrières, Vincent
N1 - Publisher Copyright:
© 2015 The Royal Society of Chemistry.
PY - 2015/8/21
Y1 - 2015/8/21
N2 - Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents.
AB - Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents.
UR - http://www.scopus.com/inward/record.url?scp=84938352875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938352875&partnerID=8YFLogxK
U2 - 10.1039/c5ob00563a
DO - 10.1039/c5ob00563a
M3 - Review article
C2 - 26130402
AN - SCOPUS:84938352875
SN - 1477-0520
VL - 13
SP - 8393
EP - 8404
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 31
ER -