TY - JOUR
T1 - Left ventricular mass index as 'outcome' related to circadian blood pressure characteristics
AU - Chen, C. H.
AU - Cornelissen-Guillaume, Germaine G
AU - Halberg, F.
AU - Fiser, B.
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Hourly blood pressure data collected with an ambulatory monitor for 24 hours on 424 patients were chrono-meta-analyzed to check on an earlier finding that patients with an excessive circadian blood pressure amplitude (above the upper 95% prediction limit of healthy peers matched by gender and age), a condition called circadian hyper-amplitude-tension (CHAT), are at a greatly increased vascular disease risk. The left ventricular mass index (LVMI), determined echographically on each subject, served as a surrogate outcome measure. Patients with CHAT were found to have an elevated LVMI, thus corroborating earlier results from a 6-year prospective study based on the actual incidence of morbid events.
AB - Hourly blood pressure data collected with an ambulatory monitor for 24 hours on 424 patients were chrono-meta-analyzed to check on an earlier finding that patients with an excessive circadian blood pressure amplitude (above the upper 95% prediction limit of healthy peers matched by gender and age), a condition called circadian hyper-amplitude-tension (CHAT), are at a greatly increased vascular disease risk. The left ventricular mass index (LVMI), determined echographically on each subject, served as a surrogate outcome measure. Patients with CHAT were found to have an elevated LVMI, thus corroborating earlier results from a 6-year prospective study based on the actual incidence of morbid events.
KW - Essential hypertension
KW - Excessive circadian blood pressure
KW - Left ventricular hypertrophy
KW - Owerswinging
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M3 - Article
AN - SCOPUS:0032439230
SN - 1211-3395
VL - 71
SP - 183
EP - 190
JO - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
JF - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
IS - 4
ER -