After acute myocardial infarction, left ventricular filling pressure is elevated because of systolic and/or diastolic dysfunction. The severity of the left ventricular dysfunction is influenced not only by infarct size and location but also by biochemical, neurohormonal, and peripheral vascular responses to infarction. Short-term vasodilator therapy improves left ventricular dysfunction and may influence favorably long-term prognosis in the presence of severe systolic dysfunction but not with predominant diastolic dysfunction. The chronic systolic dysfunction which may follow acute myocardial infarction also is influenced favorably by chronic vasodilator therapy.
|Original language||English (US)|
|Journal||Journal of Cardiovascular Pharmacology|
|State||Published - 1989|
Bibliographical noteFunding Information:
* This study was supported by grants from the Medical Faculty, University of Lund, the Swedish National Association against Heart and Chest Diseases and the Swedish Cancer Society. Reprint requests to: Dr. J.A. Dahlstrom, Department of Clinical Physiology, University of Lund, Almanna Sjukhuset, S-214 01 Malmb, Sweden.
- Vasodilator drugs