Learning Curve Associated with ClearPoint Neuronavigation System: A Case Series

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3 Scopus citations


Background: The ClearPoint neuronavigation system affords real-time magnetic resonance imaging (MRI) guidance during stereotactic procedures. While such information confers potential clinical benefits, additional operative time may be needed. Methods: We conducted a retrospective analysis of procedural time associated with ClearPoint Stereotaxis, with hypothesis that this procedural time is comparable with that associated with frame-based biopsy. Results: Of the 52 patients evaluated, the total procedural time for ClearPoint stereotactic biopsy averaged 150.0 (±40.4) minutes, of which 111.5 (±16.5) minutes were dedicated to real-time MRI acquisition and trajectory adjustment. This procedural time is within the range of those reported for frame-based needle biopsies. Approximately 5 minutes of the procedural time is related to the mounting of the MRI-compatible stereotactic frame. Based on the procedural time, we estimate that four cases are required in the learning curve to achieve this efficiency. Efficient algorithms for distortion corrections and isocenter localization are keys to ClearPoint stereotaxis. Routine quality assurance/control after each MRI software update and institutional information technology maintenance also contribute to efficiency. Real-time MRI is essential for definitive diagnosis in select cases. Conclusions: ClearPoint stereotactic needle biopsy can be achieved in time frames comparable to frame-based stereotaxis. However, procedural efficiency requires 4 “learning curve” cases as well as vigilance in terms of MR distortion correction and information technology maintenance.

Original languageEnglish (US)
Article number100115
JournalWorld Neurosurgery: X
StatePublished - Jan 2022

Bibliographical note

Funding Information:
We thank our operating room support staff as well as the MRI technologists for supporting these procedures.

Publisher Copyright:
© 2021 The Author(s)


  • ClearPoint
  • Intracranial biopsy
  • Intracranial laser ablation
  • Neurosurgery
  • Targeted drug delivery

PubMed: MeSH publication types

  • Journal Article


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