Lead-induced cell death in testes of young rats

Neeta Adhikari, Neelima Sinha, Ram Narayan, D. K. Saxena

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Lead is a well-documented testicular toxicant. The present work was planned to study the occurrence of germ cell death after lead administration. Young growing rats were treated with 5, 10 and 20 mg kg-1 body weight of lead for 2 weeks. Cell death was assessed by employing in situ TUNEL staining, DNA electrophoresis and morphological examination of the tubules. The results showed that Pb induced significant numbers of germ cells to undergo apoptosis in the seminiferous tubules of rats treated with 20 mg kg-1 body weight. However, DNA fragmentation was not detected at any of the doses. The level of lead accumulation in the testis increased in a dose-dependent manner.

Original languageEnglish (US)
Pages (from-to)275-277
Number of pages3
JournalJournal of Applied Toxicology
Issue number4
StatePublished - Aug 29 2001
Externally publishedYes


  • Lead
  • Rat
  • Testis


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