Latino risk-adjusted mortality in the men screened for the Multiple Risk Factor Intervention Trial

Avis J. Thomas, Lynn E Eberly, Jim Neaton, George Davey Smith

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Latinos are now the largest minority in the United States, but their distinctive health needs and mortality patterns remain poorly understood. Proportional hazards regressions were used to compare Latino versus White risk- and income-adjusted mortality over 25 years' follow-up from 5,846 Latino and 300,647 White men screened for the Multiple Risk Factor Intervention Trial. Men were aged 35-57 years and residing in 14 states when screened in 1973-1975. Data on coronary heart disease risk factors, self-reported race/ethnicity, and home addresses were obtained at baseline; income was estimated by linking addresses to census data. Mortality follow-up through 1999 was obtained using the National Death Index. The fully adjusted Latino/White hazard ratio for all-cause mortality was 0.82 (95% confidence interval (CI): 0.77, 0.87), based on 1,085 Latino and 73,807 White deaths; this pattern prevailed over time and across states (thus, likely across Latino subgroups). Hazard ratios were significantly greater than one for stroke (hazard ratio = 1.30, 95% CI: 1.01, 1.68), liver cancer (hazard ratio = 2.02, 95% CI: 1.21, 3.37), and infection (hazard ratio = 1.69, 95% CI: 1.24, 2.32). A substudy found only minor racial/ethnic differences in the quality of Social Security numbers, birth dates, soundex-adjusted names, and National Death Index searches. Results were not likely an artifact of return migration or incomplete mortality data.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalAmerican journal of epidemiology
Issue number6
StatePublished - Sep 2005

Bibliographical note

Funding Information:
This work was supported by National Heart, Lung, and Blood Institute grants R01-HL-43232 and R01-HL-68140.


  • Cardiovascular diseases
  • Cerebrovascular accident
  • Diabetes mellitus, type 2
  • Emigration and immigration
  • Ethnology
  • Hispanic Americans
  • Liver neoplasms
  • Social class


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