Latent class analysis of diagnostic agreement

John S. Uebersax, William M. Grove

Research output: Contribution to journalArticle

98 Scopus citations


We describe methods based on latent class analysis for analysis and interpretation of agreement on dichotomous diagnostic ratings. This approach formulates agreement in terms of parameters directly related to diagnostic accuracy and leads to many practical applications, such as estimation of the accuracy of individual ratings and the extent to which accuracy may improve with multiple opinions. We describe refinements in the estimation of parameters for varying panel designs, and apply latent class methods successfully to examples of medical agreement data that include data previously found to be poorly fitted by two‐class models. Latent class techniques provide a powerful and flexible set of tools to analyse diagnostic agreement and one should consider them routinely in the analysis of such data.

Original languageEnglish (US)
Pages (from-to)559-572
Number of pages14
JournalStatistics in Medicine
Issue number5
StatePublished - May 1990

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