Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti, Riccardo Calvani, Jameson DuPree, Hazel A. Lees, Silvia Giovannini, Dong Oh Seo, Thomas W. Buford, Kindal Sweet, Drake Morgan, Kevin Y.E. Strehler, Debra Diz, Stephen E. Borst, Natasha Moningka, Karina Y Krotova, Christy S. Carter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.

Original languageEnglish (US)
Pages (from-to)1061-1075
Number of pages15
JournalAGE
Volume35
Issue number4
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Enalapril
Nitric Oxide
Skeletal Muscle
Muscle Strength
Angiotensin-Converting Enzyme Inhibitors
Oxidative Stress
Apoptosis
Muscles

Keywords

  • ACE inhibitors
  • Aging
  • Glucose tolerance
  • Inflammation
  • L-NAME
  • MTOR
  • Mitochondria
  • Nitric oxide synthase (NOS) isoforms

Cite this

Marzetti, E., Calvani, R., DuPree, J., Lees, H. A., Giovannini, S., Seo, D. O., ... Carter, C. S. (2013). Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. AGE, 35(4), 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. / Marzetti, Emanuele; Calvani, Riccardo; DuPree, Jameson; Lees, Hazel A.; Giovannini, Silvia; Seo, Dong Oh; Buford, Thomas W.; Sweet, Kindal; Morgan, Drake; Strehler, Kevin Y.E.; Diz, Debra; Borst, Stephen E.; Moningka, Natasha; Krotova, Karina Y; Carter, Christy S.

In: AGE, Vol. 35, No. 4, 01.08.2013, p. 1061-1075.

Research output: Contribution to journalArticle

Marzetti, E, Calvani, R, DuPree, J, Lees, HA, Giovannini, S, Seo, DO, Buford, TW, Sweet, K, Morgan, D, Strehler, KYE, Diz, D, Borst, SE, Moningka, N, Krotova, KY & Carter, CS 2013, 'Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle', AGE, vol. 35, no. 4, pp. 1061-1075. https://doi.org/10.1007/s11357-012-9428-4
Marzetti, Emanuele ; Calvani, Riccardo ; DuPree, Jameson ; Lees, Hazel A. ; Giovannini, Silvia ; Seo, Dong Oh ; Buford, Thomas W. ; Sweet, Kindal ; Morgan, Drake ; Strehler, Kevin Y.E. ; Diz, Debra ; Borst, Stephen E. ; Moningka, Natasha ; Krotova, Karina Y ; Carter, Christy S. / Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. In: AGE. 2013 ; Vol. 35, No. 4. pp. 1061-1075.
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