Late growth and changes in body composition influence odds of developing retinopathy of prematurity among preterm infants

Ellen C. Ingolfsland; Jacob L. Haapala; Lauren A. Buckley; Ellen W. Demarath; Sixto F. Guiang; Sara E. Ramel

doi:10.3390/nu12010078

Late growth and changes in body composition influence odds of developing retinopathy of prematurity among preterm infants

Ellen C. Ingolfsland, Jacob L. Haapala, Lauren A. Buckley, Ellen W. Demarath, Sixto F. Guiang, Sara E. Ramel

Neonatology (Pediatrics)

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

BACKGROUND: While postnatal growth in the first month of life is known to impact retinopathy of prematurity (ROP) risk, the impact of growth later in hospitalization, during critical times of retinal vascularization, remains unknown. The purpose of this study was to assess if postnatal growth and body composition during the second half of neonatal intensive care unit hospitalization were associated with severity of retinopathy of prematurity in very low birth weight preterm infants.

METHODS: Prospective observational pilot study of 83 infants born <32 weeks gestation and <1500 g, conducted at a Level IV neonatal intensive care unit. Body composition was measured during the second half of hospitalization. Infants were evaluated for retinopathy of prematurity. Logistic regression was performed.

RESULTS: Greater gains in fat mass, fat-free mass, and percent body fat from 32 to 37 weeks postmenstrual age and higher % body fat at term postmenstrual age were associated with decreased odds of ≥stage 2 retinopathy of prematurity ( p < 0.05).

CONCLUSIONS: Improved growth later in neonatal intensive care unit hospitalization and increased adiposity at term may reduce odds of severe retinopathy of prematurity.

Original language	English (US)
Article number	78
Journal	Nutrients
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/nu12010078
State	Published - Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Adiposity
Body composition
Postnatal growth
Prematurity
Retinopathy of prematurity
Body Composition
Adiponectin/blood
Prospective Studies
Humans
Infant, Very Low Birth Weight/growth & development
Gestational Age
Retinopathy of Prematurity/epidemiology
Birth Weight
Infant, Premature/growth & development
Intensive Care, Neonatal
Pilot Projects
Intensive Care Units, Neonatal
Insulin-Like Growth Factor I/analysis
Odds Ratio
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 3/blood

PubMed: MeSH publication types

Observational Study
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12010078

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title = "Late growth and changes in body composition influence odds of developing retinopathy of prematurity among preterm infants",

abstract = "BACKGROUND: While postnatal growth in the first month of life is known to impact retinopathy of prematurity (ROP) risk, the impact of growth later in hospitalization, during critical times of retinal vascularization, remains unknown. The purpose of this study was to assess if postnatal growth and body composition during the second half of neonatal intensive care unit hospitalization were associated with severity of retinopathy of prematurity in very low birth weight preterm infants.METHODS: Prospective observational pilot study of 83 infants born <32 weeks gestation and <1500 g, conducted at a Level IV neonatal intensive care unit. Body composition was measured during the second half of hospitalization. Infants were evaluated for retinopathy of prematurity. Logistic regression was performed.RESULTS: Greater gains in fat mass, fat-free mass, and percent body fat from 32 to 37 weeks postmenstrual age and higher % body fat at term postmenstrual age were associated with decreased odds of ≥stage 2 retinopathy of prematurity ( p < 0.05). CONCLUSIONS: Improved growth later in neonatal intensive care unit hospitalization and increased adiposity at term may reduce odds of severe retinopathy of prematurity.",

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author = "Ingolfsland, {Ellen C.} and Haapala, {Jacob L.} and Buckley, {Lauren A.} and Demarath, {Ellen W.} and Guiang, {Sixto F.} and Ramel, {Sara E.}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jan,

doi = "10.3390/nu12010078",

language = "English (US)",

volume = "12",

journal = "Nutrients",

issn = "2072-6643",

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T1 - Late growth and changes in body composition influence odds of developing retinopathy of prematurity among preterm infants

AU - Ingolfsland, Ellen C.

AU - Haapala, Jacob L.

AU - Buckley, Lauren A.

AU - Demarath, Ellen W.

AU - Guiang, Sixto F.

AU - Ramel, Sara E.

PY - 2020/1

Y1 - 2020/1

N2 - BACKGROUND: While postnatal growth in the first month of life is known to impact retinopathy of prematurity (ROP) risk, the impact of growth later in hospitalization, during critical times of retinal vascularization, remains unknown. The purpose of this study was to assess if postnatal growth and body composition during the second half of neonatal intensive care unit hospitalization were associated with severity of retinopathy of prematurity in very low birth weight preterm infants.METHODS: Prospective observational pilot study of 83 infants born <32 weeks gestation and <1500 g, conducted at a Level IV neonatal intensive care unit. Body composition was measured during the second half of hospitalization. Infants were evaluated for retinopathy of prematurity. Logistic regression was performed.RESULTS: Greater gains in fat mass, fat-free mass, and percent body fat from 32 to 37 weeks postmenstrual age and higher % body fat at term postmenstrual age were associated with decreased odds of ≥stage 2 retinopathy of prematurity ( p < 0.05). CONCLUSIONS: Improved growth later in neonatal intensive care unit hospitalization and increased adiposity at term may reduce odds of severe retinopathy of prematurity.

AB - BACKGROUND: While postnatal growth in the first month of life is known to impact retinopathy of prematurity (ROP) risk, the impact of growth later in hospitalization, during critical times of retinal vascularization, remains unknown. The purpose of this study was to assess if postnatal growth and body composition during the second half of neonatal intensive care unit hospitalization were associated with severity of retinopathy of prematurity in very low birth weight preterm infants.METHODS: Prospective observational pilot study of 83 infants born <32 weeks gestation and <1500 g, conducted at a Level IV neonatal intensive care unit. Body composition was measured during the second half of hospitalization. Infants were evaluated for retinopathy of prematurity. Logistic regression was performed.RESULTS: Greater gains in fat mass, fat-free mass, and percent body fat from 32 to 37 weeks postmenstrual age and higher % body fat at term postmenstrual age were associated with decreased odds of ≥stage 2 retinopathy of prematurity ( p < 0.05). CONCLUSIONS: Improved growth later in neonatal intensive care unit hospitalization and increased adiposity at term may reduce odds of severe retinopathy of prematurity.

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ER -

Late growth and changes in body composition influence odds of developing retinopathy of prematurity among preterm infants

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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