Laser-illuminated nanohole arrays for multiplex plasmonic microarray sensing

Antoine Lesuffleur, Hyungsoon Im, Nathan C. Lindquist, Kwan Seop Lim, Sang Hyun Oh

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Surface plasmon resonance (SPR) imaging is a powerful technique for high-throughput, real-time, label-free characterization of molecular interactions in a microarray format. In this paper, we demonstrate SPR imaging with nanohole arrays illuminated by a laser source. Periodic nanoholes couple incident photons into SPs, obviating the need for the prism used in conventional SPR instruments, while a laser source provides the intensity, stability and spectral coherence to improve the detection sensitivity. The formation of a self-assembled monolayer of alkanethiolates on gold changed the laser transmission by more than 35%, and binding kinetics were measured in parallel from a 5×3 microarray of nanohole sensors. These results demonstrate the potential of nanohole sensors for high-throughput SPR imaging on microarrays.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalOptics Express
Issue number1
StatePublished - Jan 7 2008


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