Laser-cured fibrinogen glue to repair bleb leaks in rabbits

Martha M. Wright, Elizabeth A. Brown, Keegan MaxWell, J. Douglas Cameron, Arthur W. Walsh

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To determine whether laser-cured fibrinogen glue can close bleb leaks in rabbits. Methods: Full-thickness filtration surgery with intraoperative mitomycin and a sutured limbus-based conjunctival flap was performed in 1 eye each of 19 New Zealand albino rabbits. On the second postoperative day, a 2- to 3-mm hole was made in the bleb. In 9 rabbits, the hole was glued using fibrinogen glue with indocyanine green dye added. The glue was 'cured' with a diode laser. Eyes that had been glued and developed a subsequent leak had the glue reapplied on the day the leak was detected. Results: The glue remained on the conjunctiva for an average (mean±SD) of 1.9±1.8 days (range, 0-5 days). The last day of bleb leak for the rabbits with glued eyes was 1.6±2.4 days; for the control rabbits, it was 8.0±4.4 days (P=.001, Mann-Whitney U test). Conclusion: Laser-cured fibrinogen glue is effective in closing bleb leaks in rabbits.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalArchives of Ophthalmology
Issue number2
StatePublished - 1998


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