Laser-assisted regenerative surgical therapy for peri-implantitis: A randomized controlled clinical trial

Chin Wei Wang, Sajjad Ashnagar, Riccardo Di Gianfilippo, Michelle Arnett, Janet Kinney, Hom Lay Wang

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Background: Different surgical approaches have been proposed to treat peri-implantitis defects with limited effectiveness and predictability. Laser has been proposed as an effective tool to assist in bacterial decontamination and modulating peri-implant tissue inflammation. The aim of this pilot clinical trial was to evaluate the adjunctive benefits of Er:YAG laser irradiation for regenerative surgical therapy of peri-implantitis-associated osseous defects. Methods: Twenty-four patients diagnosed with peri-implantitis with a radiographic infrabony defect were randomized into two groups. Both test and control groups received the following treatment: open flap mechanical debridement, supracrestal implantoplasty, bone grafting using a mixture of human allograft with demineralized bone matrix human allograft putty, and then covered with acellular dermal matrix membrane. The only difference in the test group was the adjunctive use of Er:YAG laser to modulate and remove inflammatory tissue as well as to decontaminate the implant surface. Clinical assessments, including pocket depth (PD), clinical attachment level (CAL), and gingival index (GI) were performed by calibrated masked examiners for up to 6 months following surgery. Standardized radiographs were also taken to evaluate linear bone gain and defect bone fill. Student t-tests were used to analyze those clinical parameters. Results: Both groups showed significant reductions in PD, GI, and CAL gain overtime. The test group demonstrated significantly higher PD reductions at the site level compared to the control group (2.65 ± 2.14 versus 1.85 ± 1.71 mm; test versus control, P = 0.014). There were no statistical differences found in CAL gain (1.90 ± 2.28 versus 1.47 ± 1.76 mm; test versus control), GI reduction (-1.14 ± 1.15 versus -1.04 ± 0.89; test versus control), radiographic linear bone gain (1.27 ± 1.14 versus 1.08 ± 1.04 mm; test versus control) or proportional defect size reduction (- 24.46 ± 19.00% versus -15.19 ± 23.56%; test versus control). There was a positive trend for test patients on PD reduction and CAL gain found in narrow infrabony defects. Major membrane exposure negatively impaired the overall treatment outcome of CAL gain (2.47 ± 1.84 versus 1.03 ± 1.48 mm; no/minor versus major exposure, P = 0.051) and PD reduction in the test group (-3.63 ± 2.11 versus -1.66 ± 1.26 mm, P = 0.049). Conclusion: This pilot study indicated using laser irradiation during peri-implantitis regenerative therapy may aid in better probing PD reduction. Nonetheless, a larger sample size and longer follow-up is needed to confirm if Er:YAG laser irradiation provides additional clinical benefits for peri-implantitis regenerative therapy ( NCT03127228).

Original languageEnglish (US)
Pages (from-to)378-388
Number of pages11
JournalJournal of periodontology
Issue number3
StatePublished - Aug 25 2020

Bibliographical note

Funding Information:
The authors thank Dr. William Giannobile (Department of Periodontics and Oral Medicine, the University of Michigan School of Dentistry) for his advice on the study design and critically reading the manuscript. This study was supported by grants from J. Morita (Tokyo, Japan) and the Department of Periodontics and Oral Medicine Clinical Research Fund. We also would like to thank the support from BioHorizons (Alabama, USA) for the biomaterials.

Publisher Copyright:
© 2020 American Academy of Periodontology


  • alveolar bone grafting
  • bone regeneration
  • clinical trial
  • dental implants
  • lasers
  • peri-implantitis


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