Laryngeal histoplasmosis in a kidney transplant recipient

Sarwat Khalil, Douglas W. Challener, Omar Abu-Saleh, M. Rizwan Sohail

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Histoplasma capsulatum is an endemic fungus that most oftenly causes a self-limiting illness but can result in severe infections in immunocompromised patients including pulmonary or extra-pulmonary disease. Rarely it can also cause a chronic progressive infection of the larynx. Herein, we report a case of laryngeal histoplasmosis in a kidney transplant patient who presented with progressive symptoms of several weeks of hoarseness, dysphagia and odynophagia. Laryngoscopic examination revealed thick plaques in the oropharynx with surrounding hyper-erythema and histopathology showed numerous intracellular yeasts forms consistent with H capsulatum. Patient was initiated on treatment with itraconazole. Infection of the larynx due to H capsulatum is highly uncommon and therefore can result in an inappropriate or delayed diagnosis. A review of literature showed four previously reported cases of laryngeal histoplasmosis in patients with solid organ transplant. This is the first case series of laryngeal histoplasmosis in transplant recipients.

Original languageEnglish (US)
Article numbere13102
JournalTransplant Infectious Disease
Volume21
Issue number4
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • histoplasmosis
  • infection
  • kidney transplant
  • laryngitis

PubMed: MeSH publication types

  • Case Reports
  • Journal Article
  • Review

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