Large-scale mammalian cell culture

Wei Shou Hu, John G. Aunins

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Mammalian cell culture continues to draw major research efforts. A great deal of progress has recently been made in cellular physiology, especially in factors adversely affecting cell growth or viability. Through molecular genetic manipulation, cells are more readily cultivated in a medium free of animal proteins. Achieving a high cell concentration and high viability continue to be common themes in engineering research. The need to implement a control policy for fed-batch and perfusion cultures has prompted increased efforts in process monitoring and control. Integrating these advances will be beneficial for ensuring product quality and process consistency.

Original languageEnglish (US)
Pages (from-to)148-153
Number of pages6
JournalCurrent opinion in biotechnology
Issue number2
StatePublished - Apr 1997


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