Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state

Dita Mayerova, Evan A. Parke, Laura S. Bursch, Oludare A. Odumade, Kristin A. Hogquist

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antigen-presenting cell that initiated this response was the epidermal Langerhans cell. Naive CD8 T cells proliferated extensively, migrated to tissues, developed effector function, and were capable of making a recall response. These features are very different from the abortive activation of CD8 T cells that occurred in response to the same antigen presented by APC from other tissues. Furthermore, tolerance was dominant when the antigen was presented by both Langerhans cells and other APC. These data suggest that Langerhans cells do not have tolerogenic properties in the steady state.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalImmunity
Volume21
Issue number3
DOIs
StatePublished - Sep 1 2004

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