Langerhans cell histiocytosis of the digestive tract identified on an upper gastrointestinal examination

Markus Zei, Arthur B. Meyers, Kevin P. Boyd, Catherine Larson-Nath, Mariko Suchi

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Langerhans cell histiocytosis (LCH) with involvement of the gastrointestinal tract is rare and typically identified in patients with systemic disease. We describe a 16-month-old girl who initially presented with bilious vomiting, failure to thrive and a rash. An upper gastrointestinal (GI) examination revealed loss of normal mucosal fold pattern and luminal narrowing within the duodenum, prompting endoscopic biopsy. Langerhans cell histiocytosis of the digestive tract was confirmed by histopathology. A skeletal survey and skin biopsy identified other systemic lesions. Although uncommon, it is important to consider LCH in the differential diagnosis for gastrointestinal symptoms of unclear origin, especially when seen with concurrent rash. Findings of gastrointestinal involvement on upper GI examination include loss of normal mucosal fold pattern and luminal narrowing in the few published case reports.

Original languageEnglish (US)
Pages (from-to)1341-1344
Number of pages4
JournalPediatric Radiology
Volume46
Issue number9
DOIs
StatePublished - Aug 1 2016

Keywords

  • Adolescent
  • Duodenum
  • Gastrointestinal tract
  • Langerhans cell histiocytosis
  • Upper GI examination

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