Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

Xingbao Li, Raffaella Ricci, Charles H. Large, Berry Anderson, Ziad Nahas, Mark S. George

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo. Resting motor threshold (RMT), cortical silent period (CSP) and motor evoked potential recruitment curves (RC) were assessed at baseline and 3 h after administration of each medication (or placebo). Lamotrigine caused a significant increase (63.32 vs. 69.25) in the RMT, compared with an insignificant increase following valproic acid (62.50 vs. 63.35), and a decrease (62.60 vs. 62.36) following placebo (F 2,26 = 18.58, P < 0.0001). No significant difference in CSP was found between placebo and drugs (F 2,26 = 0.119, P > 0.05). RCs were significantly suppressed by lamotrigine (t = 2.07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS.

Original languageEnglish (US)
Pages (from-to)423-429
Number of pages7
JournalJournal of Neural Transmission
Volume116
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Lamotrigine
  • Motorcortical excitability
  • Transcranial magnetic stimulation
  • Valproic acid

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