TY - JOUR
T1 - Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability
AU - Li, Xingbao
AU - Ricci, Raffaella
AU - Large, Charles H.
AU - Anderson, Berry
AU - Nahas, Ziad
AU - George, Mark S.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo. Resting motor threshold (RMT), cortical silent period (CSP) and motor evoked potential recruitment curves (RC) were assessed at baseline and 3 h after administration of each medication (or placebo). Lamotrigine caused a significant increase (63.32 vs. 69.25) in the RMT, compared with an insignificant increase following valproic acid (62.50 vs. 63.35), and a decrease (62.60 vs. 62.36) following placebo (F 2,26 = 18.58, P < 0.0001). No significant difference in CSP was found between placebo and drugs (F 2,26 = 0.119, P > 0.05). RCs were significantly suppressed by lamotrigine (t = 2.07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS.
AB - To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo. Resting motor threshold (RMT), cortical silent period (CSP) and motor evoked potential recruitment curves (RC) were assessed at baseline and 3 h after administration of each medication (or placebo). Lamotrigine caused a significant increase (63.32 vs. 69.25) in the RMT, compared with an insignificant increase following valproic acid (62.50 vs. 63.35), and a decrease (62.60 vs. 62.36) following placebo (F 2,26 = 18.58, P < 0.0001). No significant difference in CSP was found between placebo and drugs (F 2,26 = 0.119, P > 0.05). RCs were significantly suppressed by lamotrigine (t = 2.07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS.
KW - Lamotrigine
KW - Motorcortical excitability
KW - Transcranial magnetic stimulation
KW - Valproic acid
UR - http://www.scopus.com/inward/record.url?scp=67349240396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349240396&partnerID=8YFLogxK
U2 - 10.1007/s00702-009-0195-z
DO - 10.1007/s00702-009-0195-z
M3 - Article
C2 - 19238517
AN - SCOPUS:67349240396
VL - 116
SP - 423
EP - 429
JO - Acta Neurovegetativa
JF - Acta Neurovegetativa
SN - 0375-9245
IS - 4
ER -