TY - JOUR
T1 - Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplant
AU - Luscri, Nathan
AU - Mauer, Michael
AU - Sarafoglou, Kyriakie
AU - Moran, Antoinette
AU - Tolar, Jakub
PY - 2009/8
Y1 - 2009/8
N2 - Lactic acidosis together with hypoglycemia in the face of hematologic malignancy is a grave development. A 7-year-old male with pre-B-cell ALL following hematopoietic cell transplant was admitted to our hospital in his second relapse. On hospital days 4 and 5, he developed refractory hypoglycemia, lactic acidosis, central respiratory failure, and acute renal failure. Bicarbonate infusion, B vitamins, and hemodialysis were not effective. Care was withdrawn on hospital day 9. Further understanding of the mechanisms that cause the combined onset of lactic acidosis and hypoglycemia will help clinicians in implementing timely therapies that may reduce mortality.
AB - Lactic acidosis together with hypoglycemia in the face of hematologic malignancy is a grave development. A 7-year-old male with pre-B-cell ALL following hematopoietic cell transplant was admitted to our hospital in his second relapse. On hospital days 4 and 5, he developed refractory hypoglycemia, lactic acidosis, central respiratory failure, and acute renal failure. Bicarbonate infusion, B vitamins, and hemodialysis were not effective. Care was withdrawn on hospital day 9. Further understanding of the mechanisms that cause the combined onset of lactic acidosis and hypoglycemia will help clinicians in implementing timely therapies that may reduce mortality.
KW - Acute lymphoblastic leukemia
KW - Bone marrow transplant
KW - Hematopoietic cell transplant
KW - Hypoglycemia
KW - Lactic acidosis
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U2 - 10.1002/pbc.22010
DO - 10.1002/pbc.22010
M3 - Article
C2 - 19405138
AN - SCOPUS:67649983586
SN - 1545-5009
VL - 53
SP - 223
EP - 225
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 2
ER -