TY - JOUR
T1 - Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma
T2 - Report of a Case and Review of Literature
AU - Argyris, Prokopios P.
AU - Pambuccian, Stefan E.
AU - Cayci, Zuzan
AU - Singh, Charanjeet
AU - Tosios, Konstantinos I.
AU - Koutlas, Ioannis G.
PY - 2013/3
Y1 - 2013/3
N2 - Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.
AB - Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.
KW - Adenoid cystic carcinoma
KW - High grade transformation
KW - Immunohistochemistry
KW - Lacrimal gland
KW - Pathology
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U2 - 10.1007/s12105-012-0383-2
DO - 10.1007/s12105-012-0383-2
M3 - Article
C2 - 22829347
AN - SCOPUS:84874965769
SN - 1936-055X
VL - 7
SP - 85
EP - 92
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 1
ER -
