Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Prokopios P. Argyris, Stefan E. Pambuccian, Zuzan Cayci, Charanjeet Singh, Konstantinos I. Tosios, Ioannis G. Koutlas

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalHead and Neck Pathology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Adenoid cystic carcinoma
  • High grade transformation
  • Immunohistochemistry
  • Lacrimal gland
  • Pathology

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