Lack of usefulness of electron beam computed tomography for detecting coronary allograft vasculopathy

Norman B. Ratliff, Charles R. Jorgensen, Fredarick L. Gobel, Morrison Hodges, Thomas Knickelbine, Mark R. Pritzker

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Fifty-five patients with cardiac allografts were studied by electron beam computed tomography for coronary calcification (EBCT CC) and coronary arteriography, and from the latter, a coronary index was calculated using the size, degree of obstruction, and linear extent of disease of each vessel. There was a significant correlation between EBCT CC score and coronary index, but receiver-operating characteristic (ROC) analysis demonstrated unsatisfactory performance of EBCT CC, and 6 patients had no coronary calcification despite having very abnormal coronary indexes. There are pathologic differences between coronary allograft vasculopathy and atherosclerosis, and correspondingly, EBCT CC has limited usefulness in the cardiac transplant population.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalAmerican Journal of Cardiology
Volume94
Issue number2
DOIs
StatePublished - Jul 15 2004
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Minneapolis Heart Institute Foundation, Minneapolis, Minnesota.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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