Lack of Linkage between Hereditary Angioedema and the A and B Loci of the HLA System

Malcolm N Blumenthal, A. P. Dalmasso, B. Roitman, J. Kelly, H. Noreen, L. Emmy, N. R. Mendell, E. J. Yunis

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Abstract. A large, 81 member, four‐generation black family with hereditary angioedema is reported with regards to its clinical course and the association with the histocompatibility system. No mortality was seen related directly to the disease. Assuming that this trait is autosomal dominant it appeared to have no linkage with the histocompatibility system as noted by an estimated recombination rate in males and females of 0.5 and a maximum lod score of 0.0. Further evidence of no linkage is given by the fact that lod scores below 3.0 were observed for values of 0 less than 0.5.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalVox Sanguinis
Volume35
Issue number3
DOIs
StatePublished - Sep 1978

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