Lack of Interaction of Gabapentin with Carbamazepine or Valproate

Louis L. Radulovic; B. J. Wilder; Ilo E. Leppik; Howard N. Bockbrader; Tsun Chang; Edward L. Posvar; Allen J. Sedman; Basim M. Uthman; Gary R. Erdman

doi:10.1111/j.1528-1157.1994.tb02926.x

Lack of Interaction of Gabapentin with Carbamazepine or Valproate

Louis L. Radulovic, B. J. Wilder, Ilo E. Leppik, Howard N. Bockbrader, Tsun Chang, Edward L. Posvar, Allen J. Sedman, Basim M. Uthman, Gary R. Erdman

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Summary: Gabapentin (GBP) studies were conducted in patients with epilepsy receiving carbamazepine (CBZ, n= 12) or valproate (VPA, n = 14) monotherapy. The effects of GBP coadministration on steady‐state CBZ or VPA concentrations and of these antiepileptic drugs (AEDs) on GBP pharmacokinetics were investigated. GBP (400 mg) was coadministered every 8 h for 3% days with CBZ or for 5 1/3 days with VPA. GBP was well tolerated. Mean steady‐state plasma CBZ/CBZ‐10, ll‐epoxide (CBZ‐E) and serum VPA concentrations before, during, and after GBP administration were not significantly different. Mean steady‐state GBP pharmacokinetic parameters during CBZ or VPA coadministration were similar to steady‐state parameters reported in healthy subjects. Thus, no pharmacokinetic interaction exists between CBZ or VPA and GBP. No dosage adjustment is necessary when GBP and CBZ or VPA are coadministered.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	Epilepsia
Volume	35
Issue number	1
DOIs	https://doi.org/10.1111/j.1528-1157.1994.tb02926.x
State	Published - Jan 1994

Keywords

Anticonvulsants
Drug interaction‐carbamazepine
Gabapentin
Pharmacokinetics
Valproate‐Drug toxicity

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10.1111/j.1528-1157.1994.tb02926.x

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title = "Lack of Interaction of Gabapentin with Carbamazepine or Valproate",

abstract = "Summary: Gabapentin (GBP) studies were conducted in patients with epilepsy receiving carbamazepine (CBZ, n= 12) or valproate (VPA, n = 14) monotherapy. The effects of GBP coadministration on steady‐state CBZ or VPA concentrations and of these antiepileptic drugs (AEDs) on GBP pharmacokinetics were investigated. GBP (400 mg) was coadministered every 8 h for 3% days with CBZ or for 5 1/3 days with VPA. GBP was well tolerated. Mean steady‐state plasma CBZ/CBZ‐10, ll‐epoxide (CBZ‐E) and serum VPA concentrations before, during, and after GBP administration were not significantly different. Mean steady‐state GBP pharmacokinetic parameters during CBZ or VPA coadministration were similar to steady‐state parameters reported in healthy subjects. Thus, no pharmacokinetic interaction exists between CBZ or VPA and GBP. No dosage adjustment is necessary when GBP and CBZ or VPA are coadministered.",

keywords = "Anticonvulsants, Drug interaction‐carbamazepine, Gabapentin, Pharmacokinetics, Valproate‐Drug toxicity",

author = "Radulovic, {Louis L.} and Wilder, {B. J.} and Leppik, {Ilo E.} and Bockbrader, {Howard N.} and Tsun Chang and Posvar, {Edward L.} and Sedman, {Allen J.} and Uthman, {Basim M.} and Erdman, {Gary R.}",

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doi = "10.1111/j.1528-1157.1994.tb02926.x",

language = "English (US)",

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T1 - Lack of Interaction of Gabapentin with Carbamazepine or Valproate

AU - Radulovic, Louis L.

AU - Wilder, B. J.

AU - Leppik, Ilo E.

AU - Bockbrader, Howard N.

AU - Chang, Tsun

AU - Posvar, Edward L.

AU - Sedman, Allen J.

AU - Uthman, Basim M.

AU - Erdman, Gary R.

PY - 1994/1

Y1 - 1994/1

N2 - Summary: Gabapentin (GBP) studies were conducted in patients with epilepsy receiving carbamazepine (CBZ, n= 12) or valproate (VPA, n = 14) monotherapy. The effects of GBP coadministration on steady‐state CBZ or VPA concentrations and of these antiepileptic drugs (AEDs) on GBP pharmacokinetics were investigated. GBP (400 mg) was coadministered every 8 h for 3% days with CBZ or for 5 1/3 days with VPA. GBP was well tolerated. Mean steady‐state plasma CBZ/CBZ‐10, ll‐epoxide (CBZ‐E) and serum VPA concentrations before, during, and after GBP administration were not significantly different. Mean steady‐state GBP pharmacokinetic parameters during CBZ or VPA coadministration were similar to steady‐state parameters reported in healthy subjects. Thus, no pharmacokinetic interaction exists between CBZ or VPA and GBP. No dosage adjustment is necessary when GBP and CBZ or VPA are coadministered.

AB - Summary: Gabapentin (GBP) studies were conducted in patients with epilepsy receiving carbamazepine (CBZ, n= 12) or valproate (VPA, n = 14) monotherapy. The effects of GBP coadministration on steady‐state CBZ or VPA concentrations and of these antiepileptic drugs (AEDs) on GBP pharmacokinetics were investigated. GBP (400 mg) was coadministered every 8 h for 3% days with CBZ or for 5 1/3 days with VPA. GBP was well tolerated. Mean steady‐state plasma CBZ/CBZ‐10, ll‐epoxide (CBZ‐E) and serum VPA concentrations before, during, and after GBP administration were not significantly different. Mean steady‐state GBP pharmacokinetic parameters during CBZ or VPA coadministration were similar to steady‐state parameters reported in healthy subjects. Thus, no pharmacokinetic interaction exists between CBZ or VPA and GBP. No dosage adjustment is necessary when GBP and CBZ or VPA are coadministered.

KW - Anticonvulsants

KW - Drug interaction‐carbamazepine

KW - Gabapentin

KW - Pharmacokinetics

KW - Valproate‐Drug toxicity

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Lack of Interaction of Gabapentin with Carbamazepine or Valproate

Abstract

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