Lack of Efficacy of Haemophilus b Polysaccharide Vaccine in Minnesota

Michael T. Osterholm, Joan H. Rambeck, Karen E. White, Jean L. Jacobs, Lynne M. Pierson, James D. Neaton, Craig W. Hedberg, Kristine L. Macdonald, Dan M. Granoff

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

We evaluated the efficacy of Haemophilus b polysaccharide vaccine in children in Minnesota using a case-control study. The vaccine became available in Minnesota in August 1985. During the subsequent 28 months, 88 cases of invasive H influenzae type b disease were identified in children 24 to 71 months of age, the group targeted for vaccination. Of the 88 cases, 36 (41%) occurred in vaccinated children. Fifty-eight (33%) of 176 controls were vaccinated during a similar period. The vaccine’s protective efficacy for children with any history of vaccination was -58% (95% confidence interval = -204% to 18%). The vaccine’s protective efficacy for children who were most likely to be protected by vaccination was -55% (95% confidence interval = -238% to 29%). Our results indicate that vaccination with Haemophilus b polysaccharide vaccine had no effect in preventing H influenzae type b disease in Minnesota children.

Original languageEnglish (US)
Pages (from-to)1423-1428
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume260
Issue number10
DOIs
StatePublished - Sep 9 1988

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