Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man

D. E. Holloway, S. W. Hutton, F. J. Peterson, W. C. Duane

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The influence of experimentally induced subclinical ascorbic acid deficiency upon antipyrine metabolism was assessed in five healthy male volunteers maintained in a hospital metabolic ward and fed a controlled diet deficient in ascorbic acid. Antipyrine pharmacokinetic parameters were determined four times during the study: at the end of an initial control period, after 28 and 63 days of depletion, and at the end of a second control period. No differences in antipyrine metabolism were observed despite the fact that the subjects had plasma ascorbate levels indicative of vitamin C deficiency (i.e., plasma levels less than 0.3 mg/dl) for 5 days (28 day-depletion) or 40 days (63 day-depletion). This experiment demonstrates that pronounced ascorbic acid deficiency of relatively short duration does not alter antipyrine metabolism in man.

Original languageEnglish (US)
Pages (from-to)917-924
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume35
Issue number5
StatePublished - May 1982

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Ascorbic Acid Deficiency
Antipyrine
Ascorbic Acid
Healthy Volunteers
Pharmacokinetics
Diet

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Holloway, D. E., Hutton, S. W., Peterson, F. J., & Duane, W. C. (1982). Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man. American Journal of Clinical Nutrition, 35(5), 917-924.

Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man. / Holloway, D. E.; Hutton, S. W.; Peterson, F. J.; Duane, W. C.

In: American Journal of Clinical Nutrition, Vol. 35, No. 5, 05.1982, p. 917-924.

Research output: Contribution to journalArticle

Holloway, DE, Hutton, SW, Peterson, FJ & Duane, WC 1982, 'Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man', American Journal of Clinical Nutrition, vol. 35, no. 5, pp. 917-924.
Holloway, D. E. ; Hutton, S. W. ; Peterson, F. J. ; Duane, W. C. / Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man. In: American Journal of Clinical Nutrition. 1982 ; Vol. 35, No. 5. pp. 917-924.
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