Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man

D. E. Holloway, S. W. Hutton, F. J. Peterson, W. C. Duane

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The influence of experimentally induced subclinical ascorbic acid deficiency upon antipyrine metabolism was assessed in five healthy male volunteers maintained in a hospital metabolic ward and fed a controlled diet deficient in ascorbic acid. Antipyrine pharmacokinetic parameters were determined four times during the study: at the end of an initial control period, after 28 and 63 days of depletion, and at the end of a second control period. No differences in antipyrine metabolism were observed despite the fact that the subjects had plasma ascorbate levels indicative of vitamin C deficiency (i.e., plasma levels less than 0.3 mg/dl) for 5 days (28 day-depletion) or 40 days (63 day-depletion). This experiment demonstrates that pronounced ascorbic acid deficiency of relatively short duration does not alter antipyrine metabolism in man.

Original languageEnglish (US)
Pages (from-to)917-924
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume35
Issue number5
StatePublished - May 1982

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