Lack of donor-specific tolerance in mice with established anti-Ia-treated islet allografts

Charles E. Morrow, David E R Sutherland, Michael W. Steffes, John S. Najarian, Fritz H. Bach

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Pancreatic islet allografts pretreated in vitro with monoclonal Ia antibody and transplanted beneath the renal capsule result in normoglycemia beyond 100 days in streptozotocin-induced diabetic recipient mice that differ only at H-2 K, H-2 K + I, or H-2 K + I + D from the donors. Mice with established islet allografts are not tolerant of donor-specific skin or islet antigens, but rather reject donor skin grafts in an accelerated fashion. Established anti-Ia antibody pretreated islet allografts continue to express target antigens and remain susceptible to rejection after challenge with donor skin grafts.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalTransplantation
Volume36
Issue number6
DOIs
StatePublished - Dec 1983

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