Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists

Susan M. Lou; Kelly L. Larkin; Kevin Winthrop; James T. Rosenbaum; Massimo Accorinti; Sofia Androudi; Lourdes Arellanes; Matthias Becker; Bahram Bodaghi; Soon Phaik Chee; Smet De Smet; D. Marc; Michal Kramer; Genevieve Larkin; Sue Lightman; Lyndell Lim; Juan Lopez; Friederike Mackensen; Peter McCluskey; Cristina Muccioli; A. Okada Annabelle; Narciss Okhravi; Daniel Vasconcelos-Santos; Peter Mc Cluskey Zamir; Manfred Zierhut; Nisha Acharya; Andrea Birnbaum; Nicholas J. Butler; David Callanan; Emmett Cunningham; Sam Dahr; Janet L. Davis; Larissa Derzko-Dzulynsky; James Dunn; Albert O. Edwards; Lisa Faia; Naomi Falk; Farzin Forooghian; C. Stephen Foster; Alan H. Friedman; Sunir Garg; Paul Gaudio; Ronald Gentile; Debra Goldstein; Douglas Jabs; Glen Jaffe; Kashyap Kansupada; Henry Kaplan; Sanjay Kedhar; Robert Beardsley; Uveitis Specialists Study Group

doi:10.3109/09273948.2014.926936

Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists

Susan M. Lou, Kelly L. Larkin, Kevin Winthrop, James T. Rosenbaum, Massimo Accorinti, Sofia Androudi, Lourdes Arellanes, Matthias Becker, Bahram Bodaghi, Soon Phaik Chee, Smet De Smet, D. Marc, Michal Kramer, Genevieve Larkin, Sue Lightman, Lyndell Lim, Juan Lopez, Friederike Mackensen, Peter McCluskey, Cristina MuccioliA. Okada Annabelle, Narciss Okhravi, Daniel Vasconcelos-Santos, Peter Mc Cluskey Zamir, Manfred Zierhut, Nisha Acharya, Andrea Birnbaum, Nicholas J. Butler, David Callanan, Emmett Cunningham, Sam Dahr, Janet L. Davis, Larissa Derzko-Dzulynsky, James Dunn, Albert O. Edwards, Lisa Faia, Naomi Falk, Farzin Forooghian, C. Stephen Foster, Alan H. Friedman, Sunir Garg, Paul Gaudio, Ronald Gentile, Debra Goldstein, Douglas Jabs, Glen Jaffe, Kashyap Kansupada, Henry Kaplan, Sanjay Kedhar, Robert Beardsley, Uveitis Specialists Study Group

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Purpose: To assess the approach of specialists to ocular tuberculosis (TB). Methods: The American Uveitis Society (AUS) Listserv was surveyed using two clinical cases and general questions. Results: Of 196 members, 87 responded (44.4%), of whom 64 were affiliated with practices in North America, while 23 were outside of North America. The survey provided normative data on how physicians evaluate patients with uveitis as well as opinions about ocular TB. Responses varied widely on such issues as (1) the pretest probability that a patient with granulomatous panuveitis had TB uveitis (range 1-75%) or that a patient with a risk factor for TB had ocular TB (range 0-90%); (2) the optimal duration of anti-TB therapy; and (3) whether therapy should be discontinued after 2 months in nonresponders. Conclusions: Consensus is lacking among uveitis specialists for the diagnosis or management of ocular TB.

Original language	English (US)
Pages (from-to)	25-31
Number of pages	7
Journal	Ocular Immunology and Inflammation
Volume	23
Issue number	1
DOIs	https://doi.org/10.3109/09273948.2014.926936
State	Published - Feb 1 2015

Bibliographical note

Funding Information:
See financial disclosures in Conflict of Interest form for Dr. James T. Rosenbaum This research was supported by Research to Prevent Blindness, National Eye Institute core facility grant P30EY010572, the William and Mary Bauman Foundation, and the Stan and Madelle Rosenfeld Family Trust. The Oregon Clinical and Translational Research Institute (OCTRI) also supported this publication: grant number (UL1TR000128) from the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© Informa Healthcare USA, Inc.

Keywords

Post-test probability
Pretest probability
Tuberculosis
Uveitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/09273948.2014.926936

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Lou, S. M., Larkin, K. L., Winthrop, K., Rosenbaum, J. T., Accorinti, M., Androudi, S., Arellanes, L., Becker, M., Bodaghi, B., Chee, S. P., De Smet, S., Marc, D., Kramer, M., Larkin, G., Lightman, S., Lim, L., Lopez, J., Mackensen, F., McCluskey, P., ... Uveitis Specialists Study Group (2015). Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists. Ocular Immunology and Inflammation, 23(1), 25-31. https://doi.org/10.3109/09273948.2014.926936

Lou, SM, Larkin, KL, Winthrop, K, Rosenbaum, JT, Accorinti, M, Androudi, S, Arellanes, L, Becker, M, Bodaghi, B, Chee, SP, De Smet, S, Marc, D, Kramer, M, Larkin, G, Lightman, S, Lim, L, Lopez, J, Mackensen, F, McCluskey, P, Muccioli, C, Okada Annabelle, A, Okhravi, N, Vasconcelos-Santos, D, Zamir, PMC, Zierhut, M, Acharya, N, Birnbaum, A, Butler, NJ, Callanan, D, Cunningham, E, Dahr, S, Davis, JL, Derzko-Dzulynsky, L, Dunn, J, Edwards, AO, Faia, L, Falk, N, Forooghian, F, Foster, CS, Friedman, AH, Garg, S, Gaudio, P, Gentile, R, Goldstein, D, Jabs, D, Jaffe, G, Kansupada, K, Kaplan, H, Kedhar, S, Beardsley, R & Uveitis Specialists Study Group 2015, 'Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists', Ocular Immunology and Inflammation, vol. 23, no. 1, pp. 25-31. https://doi.org/10.3109/09273948.2014.926936

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abstract = "Purpose: To assess the approach of specialists to ocular tuberculosis (TB). Methods: The American Uveitis Society (AUS) Listserv was surveyed using two clinical cases and general questions. Results: Of 196 members, 87 responded (44.4%), of whom 64 were affiliated with practices in North America, while 23 were outside of North America. The survey provided normative data on how physicians evaluate patients with uveitis as well as opinions about ocular TB. Responses varied widely on such issues as (1) the pretest probability that a patient with granulomatous panuveitis had TB uveitis (range 1-75%) or that a patient with a risk factor for TB had ocular TB (range 0-90%); (2) the optimal duration of anti-TB therapy; and (3) whether therapy should be discontinued after 2 months in nonresponders. Conclusions: Consensus is lacking among uveitis specialists for the diagnosis or management of ocular TB.",

keywords = "Post-test probability, Pretest probability, Tuberculosis, Uveitis",

author = "Lou, {Susan M.} and Larkin, {Kelly L.} and Kevin Winthrop and Rosenbaum, {James T.} and Massimo Accorinti and Sofia Androudi and Lourdes Arellanes and Matthias Becker and Bahram Bodaghi and Chee, {Soon Phaik} and {De Smet}, Smet and D. Marc and Michal Kramer and Genevieve Larkin and Sue Lightman and Lyndell Lim and Juan Lopez and Friederike Mackensen and Peter McCluskey and Cristina Muccioli and {Okada Annabelle}, A. and Narciss Okhravi and Daniel Vasconcelos-Santos and Zamir, {Peter Mc Cluskey} and Manfred Zierhut and Nisha Acharya and Andrea Birnbaum and Butler, {Nicholas J.} and David Callanan and Emmett Cunningham and Sam Dahr and Davis, {Janet L.} and Larissa Derzko-Dzulynsky and James Dunn and Edwards, {Albert O.} and Lisa Faia and Naomi Falk and Farzin Forooghian and Foster, {C. Stephen} and Friedman, {Alan H.} and Sunir Garg and Paul Gaudio and Ronald Gentile and Debra Goldstein and Douglas Jabs and Glen Jaffe and Kashyap Kansupada and Henry Kaplan and Sanjay Kedhar and Robert Beardsley and {Uveitis Specialists Study Group}",

note = "Funding Information: See financial disclosures in Conflict of Interest form for Dr. James T. Rosenbaum This research was supported by Research to Prevent Blindness, National Eye Institute core facility grant P30EY010572, the William and Mary Bauman Foundation, and the Stan and Madelle Rosenfeld Family Trust. The Oregon Clinical and Translational Research Institute (OCTRI) also supported this publication: grant number (UL1TR000128) from the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} Informa Healthcare USA, Inc.",

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AU - Lou, Susan M.

AU - Larkin, Kelly L.

AU - Winthrop, Kevin

AU - Rosenbaum, James T.

AU - Accorinti, Massimo

AU - Androudi, Sofia

AU - Arellanes, Lourdes

AU - Becker, Matthias

AU - Bodaghi, Bahram

AU - Chee, Soon Phaik

AU - De Smet, Smet

AU - Marc, D.

AU - Kramer, Michal

AU - Larkin, Genevieve

AU - Lightman, Sue

AU - Lim, Lyndell

AU - Lopez, Juan

AU - Mackensen, Friederike

AU - McCluskey, Peter

AU - Muccioli, Cristina

AU - Okada Annabelle, A.

AU - Okhravi, Narciss

AU - Vasconcelos-Santos, Daniel

AU - Zamir, Peter Mc Cluskey

AU - Zierhut, Manfred

AU - Acharya, Nisha

AU - Birnbaum, Andrea

AU - Butler, Nicholas J.

AU - Callanan, David

AU - Cunningham, Emmett

AU - Dahr, Sam

AU - Davis, Janet L.

AU - Derzko-Dzulynsky, Larissa

AU - Dunn, James

AU - Edwards, Albert O.

AU - Faia, Lisa

AU - Falk, Naomi

AU - Forooghian, Farzin

AU - Foster, C. Stephen

AU - Friedman, Alan H.

AU - Garg, Sunir

AU - Gaudio, Paul

AU - Gentile, Ronald

AU - Goldstein, Debra

AU - Jabs, Douglas

AU - Jaffe, Glen

AU - Kansupada, Kashyap

AU - Kaplan, Henry

AU - Kedhar, Sanjay

AU - Beardsley, Robert

AU - Uveitis Specialists Study Group

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PY - 2015/2/1

Y1 - 2015/2/1

N2 - Purpose: To assess the approach of specialists to ocular tuberculosis (TB). Methods: The American Uveitis Society (AUS) Listserv was surveyed using two clinical cases and general questions. Results: Of 196 members, 87 responded (44.4%), of whom 64 were affiliated with practices in North America, while 23 were outside of North America. The survey provided normative data on how physicians evaluate patients with uveitis as well as opinions about ocular TB. Responses varied widely on such issues as (1) the pretest probability that a patient with granulomatous panuveitis had TB uveitis (range 1-75%) or that a patient with a risk factor for TB had ocular TB (range 0-90%); (2) the optimal duration of anti-TB therapy; and (3) whether therapy should be discontinued after 2 months in nonresponders. Conclusions: Consensus is lacking among uveitis specialists for the diagnosis or management of ocular TB.

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KW - Post-test probability

KW - Pretest probability

KW - Tuberculosis

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Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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