Lack of association of locus coeruleus pathology with orthostatic hypotension in Parkinson's disease

Qiang Tong, Liam Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson's disease (PD) and is linked with increased mortality risk among the elderly. Although the locus coeruleus (LC) is the major source of noradrenaline (NA) modulation in the brain, its role in the pathogenesis of OH in PD remains largely elusive. Here we examined 44 well characterized postmortem brains of PD patients and available clinical data to explore the relationship between OH and LC pathology in PD. Our results failed to indicate that the LC pathology as well as the substantia nigra pathology were robustly associated with the presence of OH in PD patients, suggesting targeting LC norepinephrinergic system alone may not be sufficient to treat OH in PD.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalJournal of Parkinson's Disease
Volume11
Issue number1
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 - IOS Press. All rights reserved.

Keywords

  • Locus coeruleus
  • Norepinephrinergic
  • Orthostatic hypotension
  • Parkinson's disease
  • Substantia nigra

PubMed: MeSH publication types

  • Letter

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