Lack of an effect of short-term dehydroepiandrosterone treatment on the pentose pathway

Amelia C. Finan, Margot P. Cleary

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Isolated adipocytes and hepatocytes from two strains of rats were studied to determine if alterations in glucose metabolism and the pentose pathway account for the antiobesity action of dehydroepiandrosterone (DHEA). Isolated cells were prepared and the incorporation of 14C-labeled glucose into CO2 and lipids was determined. Fat pad weights were lower and metabolism of labeled glucose was altered in adipocytes from both Sprague-Dawley and lean Zucker rats treated with DHEA for one week. However, there was no change in the contribution of the pentose pathway to glucose metabolism when recycling of glucose was taken into account. Similar results were found in hepatocytes from lean Zucker rats. In obese Zucker rats, data from adipocytes and hepatocytes showed few clearcut differences in response to short-term DHEA treatment. In conclusion, lowered contribution of the pentose pathway to glucose metabolism does not explain the antiobesity effect of DHEA.

Original languageEnglish (US)
Pages (from-to)755-765
Number of pages11
JournalNutrition Research
Volume8
Issue number7
DOIs
StatePublished - Jul 1988

Keywords

  • Sprague-Dawley rats
  • Zucker rats
  • glucose metabolism
  • glucose-6-phosphate dehydrogenase
  • malic enzyme
  • pentose pathway

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