Lack of acrosome formation in Hrb-deficient mice

N. Kang-Decker, G. T. Mantchev, S. C. Juneja, M. A. McNiven, J. M.A. Van Deursen

Research output: Contribution to journalArticlepeer-review

219 Scopus citations


The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb, is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3 of spermiogenesis. Although proacrosomic vesicles form in spermatids that lack Hrb, the vesicles are unable to fuse, blocking acrosome development at step 2. We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis.

Original languageEnglish (US)
Pages (from-to)1531-1533
Number of pages3
Issue number5546
StatePublished - Nov 16 2001
Externally publishedYes


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