Labeling of calcitonin gene-related peptide and substance P increases in subnucleus caudalis of rabbit during maxillary sinusitis

A. K. Roche, Ioannis G. Koutlas, K. C. Kajander

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) were evaluated in subnucleus caudalis following induction of sinusitis. Three days after induction, intensity of labeling for CGRP-LI and SP-LI increased in ipsilateral subnucleus caudalis. Labeling for CGRP-LI and SP-LI appeared normal at later time points (20 and 28 days). Early changes in these neuropeptides may contribute to the inflammatory process and painful symptoms accompanying sinusitis.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalBrain Research
Volume791
Issue number1-2
DOIs
StatePublished - Apr 27 1998

Keywords

  • Inflammation
  • Neuropeptide
  • Spinal
  • Trigeminal nucleus
  • Trigeminal nucleus

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