This study presents a real-time impedimetric biosensor to detect cortisol in human serum in small volumes in the range of 1-20 µL. Continuous monitoring of cortisol is closely related to maintaining healthy physiological conditions. A 28-well plate biosensor chip was built after several steps of fabrication. The achieved nanowell array structure provides enhanced electrochemical sensitivity which enables to detect cortisol at high salt concentration of human serum. Human serum samples were collected to compare the sensor response with results from the ELISA method. The robust performance of the device was validated from the proportional response of both measurements.
|Original language||English (US)|
|Title of host publication||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Publisher||Chemical and Biological Microsystems Society|
|Number of pages||2|
|State||Published - 2020|
|Event||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online|
Duration: Oct 4 2020 → Oct 9 2020
|Name||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Conference||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020|
|Period||10/4/20 → 10/9/20|
Bibliographical noteFunding Information:
This work was sponsored by the Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) Electrical Prescriptions (ElectRx) program managed by Dr. E. V. Giesen through the DARPA Contracts Management Office Grant/Contract No HR0011-16-2-0026.
© 2020 CBMS-0001