Lab-on-a-chip technologies for single-molecule studies

Yanhui Zhao, Danqi Chen, Hongjun Yue, Jarrod B. French, Joseph Rufo, Stephen J. Benkovic, Tony Jun Huang

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Recent developments on various lab-on-a-chip techniques allow miniaturized and integrated devices to perform on-chip single-molecule studies. Fluidic-based platforms that utilize unique microscale fluidic behavior are capable of conducting single-molecule experiments with high sensitivities and throughputs, while biomolecular systems can be studied on-chip using techniques such as DNA curtains, magnetic tweezers, and solid-state nanopores. The advances of these on-chip single-molecule techniques lead to next-generation lab-on-a-chip devices, such as DNA transistors, and single-molecule real-time (SMRT) technology for rapid and low-cost whole genome DNA sequencing. In this Focus article, we will discuss some recent successes in the development of lab-on-a-chip techniques for single-molecule studies and expound our thoughts on the near future of on-chip single-molecule studies.

Original languageEnglish (US)
Pages (from-to)2183-2198
Number of pages16
JournalLab on a chip
Issue number12
StatePublished - Jun 21 2013
Externally publishedYes


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