Krebs takes a turn at cell differentiation

Stanisław Deja; Peter A. Crawford; Shawn C. Burgess

doi:10.1016/j.cmet.2022.04.005

Krebs takes a turn at cell differentiation

Stanisław Deja
, Peter A. Crawford
, Shawn C. Burgess

Research output: Contribution to journal › Comment/debate › peer-review

10 Scopus citations

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

Original language	English (US)
Pages (from-to)	658-660
Number of pages	3
Journal	Cell Metabolism
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2022.04.005
State	Published - May 3 2022

Bibliographical note

Funding Information:
The authors are grateful for support from NIH R01DK078184 (to S.C.B.), R01DK128168 (to S.C.B .), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition .

Funding Information:
The authors are grateful for support from NIH R01DK078184 (to S.C.B.),R01DK128168 (to S.C.B.), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition. The authors declare no competing interests.

Publisher Copyright:
© 2022 Elsevier Inc.

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10.1016/j.cmet.2022.04.005

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title = "Krebs takes a turn at cell differentiation",

abstract = "In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.",

author = "Stanis{\l}aw Deja and Crawford, \{Peter A.\} and Burgess, \{Shawn C.\}",

note = "Funding Information: The authors are grateful for support from NIH R01DK078184 (to S.C.B.), R01DK128168 (to S.C.B .), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition . Funding Information: The authors are grateful for support from NIH R01DK078184 (to S.C.B.),R01DK128168 (to S.C.B.), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = may,

day = "3",

doi = "10.1016/j.cmet.2022.04.005",

language = "English (US)",

volume = "34",

pages = "658--660",

journal = "Cell Metabolism",

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T1 - Krebs takes a turn at cell differentiation

AU - Deja, Stanisław

AU - Crawford, Peter A.

AU - Burgess, Shawn C.

N1 - Funding Information: The authors are grateful for support from NIH R01DK078184 (to S.C.B.), R01DK128168 (to S.C.B .), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition . Funding Information: The authors are grateful for support from NIH R01DK078184 (to S.C.B.),R01DK128168 (to S.C.B.), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition. The authors declare no competing interests. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/5/3

Y1 - 2022/5/3

N2 - In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

AB - In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

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DO - 10.1016/j.cmet.2022.04.005

M3 - Comment/debate

C2 - 35508108

AN - SCOPUS:85129346017

SN - 1550-4131

VL - 34

SP - 658

EP - 660

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Krebs takes a turn at cell differentiation

Abstract

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