Krebs takes a turn at cell differentiation

Stanisław Deja, Peter A. Crawford, Shawn C. Burgess

Research output: Contribution to journalComment/debatepeer-review

6 Scopus citations

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

Original languageEnglish (US)
Pages (from-to)658-660
Number of pages3
JournalCell Metabolism
Volume34
Issue number5
DOIs
StatePublished - May 3 2022

Bibliographical note

Funding Information:
The authors are grateful for support from NIH R01DK078184 (to S.C.B.), R01DK128168 (to S.C.B .), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition .

Funding Information:
The authors are grateful for support from NIH R01DK078184 (to S.C.B.),R01DK128168 (to S.C.B.), R01DK091538 (to P.A.C), and R01AG069781 (to P.A.C); the Robert A. Welch Foundation I-1804 (to S.C.B.); and the UT Southwestern Center for Human Nutrition. The authors declare no competing interests.

Publisher Copyright:
© 2022 Elsevier Inc.

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