Abstract
In recent years the single-probe-single-target approach in drug design has started to be smoothly replaced by the single-probe-multiple-target (or multi-target) one, where a single drug is able to tackle different, but disease-related targets in a selective manner. However, the design of multi-target drugs has been hindered by a lack of a systematic network of disease-related common pathways. The recent development of the knowledgebase of addiction-related genes (KARG) has provided important hints on how to rationally design multi-target probes by connecting experimental techniques with available network models. In this perspective, the use of KARG as a template to build knowledgebases of disease-related genes for the rational multi-target drug design is suggested. Moreover, it is proposed that building knowledgebases of disease-related genes will become a necessary and ubiquitous tool in the rational design of multi-target drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9346-9348 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 16 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 15 2008 |
| Externally published | Yes |
Bibliographical note
Funding Information:The author was supported, in part, by grants from the Minnesota Supercomputing Center and CONACYT-Mexico.
Keywords
- Breast cancer
- Common molecular networks
- Knowledgebase for addiction-related genes
- Multi-target drug design
- Network models
