Abstract
Knoevenagel adducts derived from readily available acetoxyacetone and malonic acid derivatives served as trimethylenemethane surrogates for formal 1,3-difunctionalization through a sequence of selective γ-deprotonation/α-alkylation and palladium(0)-catalyzed allylic alkylation. Herein, we report the discovery and development of a three-component 1,3-difunctionalization of Knoevenagel adducts as well as a unique palladium(0)-catalyzed branch-selective allylic alkylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 317-320 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 4 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
- 1,3-difunctionalization
- allylation
- Knoevenagel condensation
- palladium catalysis
- trimethylenemethane
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