Abstract
When suspended in water, anhydrous carbamazepine (C15H12N2O; 1) was transformed to carbamazepine dihydrate (C15H12N2O · 2H2O; 2). Compound 1 was dispersed in water at 25 °C, and an aliquot of the slurry was taken at periodic intervals and immediately filtered under conditions which removed all the physically bound water from the solid. The weight fractions of 1 and 2 in the solid were quantified by two methods: (a) by determining the weight loss on drying the solid at 60 °C under reduced pressure to a constant weight and (b) by a quantitative powder X‐ray diffraction technique. There was good agreement between the above two methods. More than 95% (w/w) of 1 was converted to 2 in 1 h and the decrease in the weight fraction of 1 with time was approximately a first‐order process.
Original language | English (US) |
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Pages (from-to) | 496-500 |
Number of pages | 5 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 80 |
Issue number | 5 |
DOIs | |
State | Published - May 1991 |
Bibliographical note
Funding Information:The financial support provided by the American Association of Colleges of Pharmacy and by the Merck Sharp and Dohme Research Laboratories is gratefully acknowledged.