Abstract
When suspended in water, anhydrous carbamazepine (C15H12N2O; 1) was transformed to carbamazepine dihydrate (C15H12N2O · 2H2O; 2). Compound 1 was dispersed in water at 25 °C, and an aliquot of the slurry was taken at periodic intervals and immediately filtered under conditions which removed all the physically bound water from the solid. The weight fractions of 1 and 2 in the solid were quantified by two methods: (a) by determining the weight loss on drying the solid at 60 °C under reduced pressure to a constant weight and (b) by a quantitative powder X‐ray diffraction technique. There was good agreement between the above two methods. More than 95% (w/w) of 1 was converted to 2 in 1 h and the decrease in the weight fraction of 1 with time was approximately a first‐order process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 496-500 |
| Number of pages | 5 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 80 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1991 |
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Kinetics of transition of anhydrous carbamazepine to carbamazepine dihydrate in aqueous suspensions. / Young, Winnie Wai Ling; Suryanarayanan, Raj.
In: Journal of Pharmaceutical Sciences, Vol. 80, No. 5, 01.01.1991, p. 496-500.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Kinetics of transition of anhydrous carbamazepine to carbamazepine dihydrate in aqueous suspensions
AU - Young, Winnie Wai Ling
AU - Suryanarayanan, Raj
PY - 1991/1/1
Y1 - 1991/1/1
N2 - When suspended in water, anhydrous carbamazepine (C15H12N2O; 1) was transformed to carbamazepine dihydrate (C15H12N2O · 2H2O; 2). Compound 1 was dispersed in water at 25 °C, and an aliquot of the slurry was taken at periodic intervals and immediately filtered under conditions which removed all the physically bound water from the solid. The weight fractions of 1 and 2 in the solid were quantified by two methods: (a) by determining the weight loss on drying the solid at 60 °C under reduced pressure to a constant weight and (b) by a quantitative powder X‐ray diffraction technique. There was good agreement between the above two methods. More than 95% (w/w) of 1 was converted to 2 in 1 h and the decrease in the weight fraction of 1 with time was approximately a first‐order process.
AB - When suspended in water, anhydrous carbamazepine (C15H12N2O; 1) was transformed to carbamazepine dihydrate (C15H12N2O · 2H2O; 2). Compound 1 was dispersed in water at 25 °C, and an aliquot of the slurry was taken at periodic intervals and immediately filtered under conditions which removed all the physically bound water from the solid. The weight fractions of 1 and 2 in the solid were quantified by two methods: (a) by determining the weight loss on drying the solid at 60 °C under reduced pressure to a constant weight and (b) by a quantitative powder X‐ray diffraction technique. There was good agreement between the above two methods. More than 95% (w/w) of 1 was converted to 2 in 1 h and the decrease in the weight fraction of 1 with time was approximately a first‐order process.
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U2 - 10.1002/jps.2600800519
DO - 10.1002/jps.2600800519
M3 - Article
VL - 80
SP - 496
EP - 500
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 5
ER -