Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties

J. M B Kaneene; S. P. Kumar; D. W. Johnson; D. J. Klausner; E. D. Sloane; Charles C Muscoplat

doi:10.1007/BF02268973

Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties

J. M B Kaneene
, S. P. Kumar
, D. W. Johnson
, D. J. Klausner
, E. D. Sloane
, Charles C Muscoplat

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPD-induced blastogenic responses when it (levamisole) was added to M.bovis sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-induced either minimal or suppressed the PPD-induced lymphocyte stimulation response in M.bovis nonexposed control lymphocytes. The implications of possible use of levamisole in cellular invitro assays for studying anergy or general unresponsiveness are discussed.

Original language	English (US)
Pages (from-to)	237-241
Number of pages	5
Journal	Veterinary Science Communications
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/BF02268973
State	Published - Jan 1 1979

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title = "Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties",

abstract = "A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPD-induced blastogenic responses when it (levamisole) was added to M.bovis sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-induced either minimal or suppressed the PPD-induced lymphocyte stimulation response in M.bovis nonexposed control lymphocytes. The implications of possible use of levamisole in cellular invitro assays for studying anergy or general unresponsiveness are discussed.",

author = "Kaneene, \{J. M B\} and Kumar, \{S. P.\} and Johnson, \{D. W.\} and Klausner, \{D. J.\} and Sloane, \{E. D.\} and Muscoplat, \{Charles C\}",

year = "1979",

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doi = "10.1007/BF02268973",

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T1 - Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties

AU - Kaneene, J. M B

AU - Kumar, S. P.

AU - Johnson, D. W.

AU - Klausner, D. J.

AU - Sloane, E. D.

AU - Muscoplat, Charles C

PY - 1979/1/1

Y1 - 1979/1/1

N2 - A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPD-induced blastogenic responses when it (levamisole) was added to M.bovis sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-induced either minimal or suppressed the PPD-induced lymphocyte stimulation response in M.bovis nonexposed control lymphocytes. The implications of possible use of levamisole in cellular invitro assays for studying anergy or general unresponsiveness are discussed.

AB - A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPD-induced blastogenic responses when it (levamisole) was added to M.bovis sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-induced either minimal or suppressed the PPD-induced lymphocyte stimulation response in M.bovis nonexposed control lymphocytes. The implications of possible use of levamisole in cellular invitro assays for studying anergy or general unresponsiveness are discussed.

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SN - 0165-7380

VL - 3

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EP - 241

JO - Veterinary Science Communications

JF - Veterinary Science Communications

IS - 1

ER -

Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties

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