Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses in Mycobacteriumbovis sensitized lymphocyties

J. M B Kaneene, S. P. Kumar, D. W. Johnson, D. J. Klausner, E. D. Sloane, Charles C Muscoplat

Research output: Contribution to journalArticlepeer-review

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Abstract

A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPD-induced blastogenic responses when it (levamisole) was added to M.bovis sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-induced either minimal or suppressed the PPD-induced lymphocyte stimulation response in M.bovis nonexposed control lymphocytes. The implications of possible use of levamisole in cellular invitro assays for studying anergy or general unresponsiveness are discussed.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalVeterinary Science Communications
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1979

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